Tetrahydrofuran → 4-chloro-N-{5-chloro-2-[hydroxy-(2-nitro-phenyl)-methyl]-pyridin-3-yl}-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide

HRID 289892

Reaction equation

HRID 289892 reaction equation
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[Cl:11][Mg:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[Cl:19][c:20]1[c:21]([C:42]([F:43])([F:44])[F:45])[cH:22][c:23]([S:26](=[O:27])(=[O:28])[N:29]([CH2:30][O:31][CH3:32])[c:33]2[c:34]([CH:40]=[O:41])[n:35][cH:36][c:37]([Cl:39])[cH:38]2)[cH:24][cH:25]1.[I:1][c:2]1[c:3]([N+:8](=[O:9])[O-:10])[cH:4][cH:5][cH:6][cH:7]1>>[c:2]1([CH:40]([c:34]2[c:33]([N:29]([S:26]([c:23]3[cH:22][c:21]([C:42]([F:43])([F:44])[F:45])[c:20]([Cl:19])[cH:25][cH:24]3)(=[O:27])=[O:28])[CH2:30][O:31][CH3:32])[cH:38][c:37]([Cl:39])[cH:36][n:35]2)[OH:41])[c:3]([N+:8](=[O:9])[O-:10])[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 69115o-IodonitrobenzeneHCID 579420984-chloro-N-(5-chloro-2-formyl-pyridin-3-yl)-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamideHCID 178478979HCID 178478979, compound

Product 1

HCID 579421384-chloro-N-{5-chloro-2-[hydroxy-(2-nitro-phenyl)-methyl]-pyridin-3-yl}-N-methoxymethyl-3-trifluoromethyl-benzenesulfonamide

Sources & evidence

ORD record
ord-7bf6ce0f5f5c4f21a6d79f989c9b2e49
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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