Dimethylformamide → 4-(4-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline

Reaction equation

[Br:1][c:2]1[c:3]2[c:7]([c:8]([CH3:11])[cH:9][cH:10]1)[NH:6][CH2:5][CH2:4]2.[Cl:12][c:13]1[n:14][cH:15][n:16][c:17]2[cH:18][c:19]([O:25][CH3:26])[c:20]([O:23][CH3:24])[cH:21][c:22]12.[O:27]=[CH:28][N:29]([CH3:30])[CH3:31]>>[Br:1][c:2]1[c:3]2[c:7]([c:8]([CH3:11])[cH:9][cH:10]1)[N:6]([c:13]1[n:14][cH:15][n:16][c:17]3[cH:18][c:19]([O:25][CH3:26])[c:20]([O:23][CH3:24])[cH:21][c:22]13)[CH2:5][CH2:4]2

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 27693644-Chloro-6,7-dimethoxyquinazoline

HCID 184732644-Bromo-7-methylindoline

Product 1

HCID 189328744-(4-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline

Sources & evidence

ORD record: ord-d04e4aa4cc84447886e7cf147582734e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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