Ethylene Oxide → 4-[7-(2-Hydroxyethyl)-3-isoquinolinyl]benzonitrile

HRID 292828

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7](-[c:12]3[cH:13][cH:14][c:15]([C:16]#[N:17])[cH:18][cH:19]3)[n:8][cH:9][c:10]2[cH:11]1.[CH2:25]1[CH2:26][O:27]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:20][CH2:21][CH2:22][CH2:23][Li:24]>>[c:2]1([CH2:25][CH2:26][OH:27])[cH:3][cH:4][c:5]2[cH:6][c:7](-[c:12]3[cH:13][cH:14][c:15]([C:16]#[N:17])[cH:18][cH:19]3)[n:8][cH:9][c:10]2[cH:11]1

Participants

Reactant 4

HCID 6354Ethylene Oxide

HCID 8028Tetrahydrofuran

HCID 671042584-(7-Bromo-3-isoquinolinyl)benzonitrile

HCID 178418339Butyllithium

Product 1

HCID 671046674-[7-(2-Hydroxyethyl)-3-isoquinolinyl]benzonitrile

Sources & evidence

ORD record: ord-01c9348ff1e04c8b846d87f7eebf92fd
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Linked notes

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