Bromide ion → 1-(2-Chloro-4-(trifluoromethyl)pyrimidin-5-yl)ethanone

Reaction equation

[Br-:15].[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH3:16][Mg+:17].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:12](=[O:13])[Cl:14])[c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1>>[Cl:1][c:2]1[n:3][cH:4][c:5]([C:12](=[O:13])[CH3:16])[c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1

Participants

Reactant 4

HCID 259Bromide ion

HCID 8028Tetrahydrofuran

HCID 27367082-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride

HCID 178477777HCID 178477777, compound

Product 1

HCID 220974501-(2-Chloro-4-(trifluoromethyl)pyrimidin-5-yl)ethanone

Sources & evidence

ORD record: ord-2dcfa203755c464fb9503c10ac9250f9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…