Tetrahydrofuran → 1H-Pyrrolo[2,3-B]pyridine, 4-chloro-1-[(1,1-dimethylethyl)dimethylsilyl]-

Reaction equation

[C:16]([CH3:17])([CH3:18])([CH3:19])[Si:20]([CH3:21])([CH3:22])[Cl:23].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[CH3:11][CH2:12][CH2:13][CH2:14][Li:15].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[nH:8][cH:9][cH:10]2>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[n:8]([Si:20]([C:16]([CH3:17])([CH3:18])[CH3:19])([CH3:21])[CH3:22])[cH:9][cH:10]2

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 28928tert-Butyldimethylsilyl chloride

HCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

HCID 178418339Butyllithium

Product 1

HCID 497590071H-Pyrrolo[2,3-B]pyridine, 4-chloro-1-[(1,1-dimethylethyl)dimethylsilyl]-

Sources & evidence

ORD record: ord-d1c2a0b1d56346ed8aef2fb985c1d3cb
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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