2-Phenylisobutyric acid → 2-Methyl-2-phenylpropanoyl chloride

HRID 29517

Reaction equation

HRID 29517 reaction equation
[CH3:1][C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:16])=O>ClCCl>[CH3:1][C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[C:3]([Cl:16])=[O:4]

Participants

4

Reactant 2

HCID 132222-Phenylisobutyric acidHCID 65578Oxalyl chloride

Product 1

HCID 123690862-Methyl-2-phenylpropanoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-Methyl-2-phenylpropionic acid (10 mmol, 1.0 eq.) and oxalyl chloride (40 mmol, 4.0 eq.) in dichloromethane (30 mL) was stirred at room temperature for 18 h. The mixture was concentrated in vacuo to afford the title compound as a yellow oil.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b388f55835f0450eb8040b6671d8a7a3
Source dataset
uspto-grants-2008_09
Patent number
US07420055B2

Linked notes

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