Dichloromethane → 2-(Chloromethyl)-3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene

Reaction equation

[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cl:30][CH2:31][Cl:32].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][c:11]([CH3:16])[c:12]([CH2:14][OH:15])[s:13]2)[cH:7][cH:8]1)([F:17])[F:18].[S:26]([Cl:27])([Cl:28])=[O:29]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][c:11]([CH3:16])[c:12]([CH2:14][Cl:28])[s:13]2)[cH:7][cH:8]1)([F:17])[F:18]

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 24386Thionyl Chloride

HCID 21986444[3-Methyl-5-(4-trifluoromethylphenyl)thien-2-yl]methanol

Product 1

HCID 159462812-(Chloromethyl)-3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene

Sources & evidence

ORD record: ord-4dc7369d31864b0386612dd71379b8eb
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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