Hydrazine hydrate (1:1) → 5,7-Dimethoxyphthalazin-1(2H)-one
Reaction equation
[CH:1]([C:3]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([O:14][CH3:15])=[CH:8][C:4]=1[C:5](O)=[O:6])=O.O.[NH2:17][NH2:18]>C(O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:9]([O:14][CH3:15])[CH:8]=[C:4]2[C:3]=1[CH:1]=[N:17][NH:18][C:5]2=[O:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The 2-formyl-3,5-dimethoxybenzoic acid (2.7 g, 13 mmol) is partially dissolved in 300 mL of ethanol, and 6.2 mL of hydrazine hydrate are then added. The mixture is refluxed for 6 hours. After cooling, the precipitate formed is filtered off and then dried. 2.3 g of a white solid are obtained (86% yield).
Workup
- temperatureThe mixture is refluxed for 6 hours
- temperatureAfter cooling
- customthe precipitate formed
- filtrationis filtered off
- customdried
Sources & evidence
- ORD record
- ord-ffc2fbeaf2ac4c7e8cb57124306c181b
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07423030B2
Reaction notes
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