Phosphorus oxychloride → 1-Chloro-4-cyclopropyl-7-methoxyphthalazine

Reaction equation

[CH:1]1([C:4]2[C:13]3[C:8](=[CH:9][C:10]([O:14][CH3:15])=[CH:11][CH:12]=3)[C:7](=O)[NH:6][N:5]=2)[CH2:3][CH2:2]1.P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)[C:4]([CH:1]2[CH2:3][CH2:2]2)=[N:5][N:6]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 692095434-cyclopropyl-7-methoxy-2H-phthalazin-1-one

Product 1

HCID 866122201-Chloro-4-cyclopropyl-7-methoxyphthalazine

Procedure

This compound is obtained according to the procedure described in 1.3. by reacting 4-cyclopropyl-7-methoxy-2H-phthalazin-1-one with phosphoryl chloride.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-bc3d669b945448c68daf2a437d3ab872
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423030B2

Reaction notes

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