Acetate → 1-(2',4'-Difluoro-1,1'-biphenyl-2-yl)ethanone

HRID 301072

Reaction equation

HRID 301072 reaction equation
[Br-:29].[Br:19][c:20]1[c:21]([C:26]([CH3:27])=[O:28])[cH:22][cH:23][cH:24][cH:25]1.[C:12](=[O:13])([O-:14])[O-:15].[C:47]([O-:48])(=[O:49])[CH3:50].[C:52]([O-:53])(=[O:54])[CH3:55].[CH3:30][CH2:31][CH2:32][CH2:33][N+:34]([CH2:35][CH2:36][CH2:37][CH3:38])([CH2:39][CH2:40][CH2:41][CH3:42])[CH2:43][CH2:44][CH2:45][CH3:46].[CH3:56][CH2:57][O:58][C:59](=[O:60])[CH3:61].[F:1][c:2]1[c:3]([B:9]([OH:10])[OH:11])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[K+:16].[K+:17].[OH2:18].[Pd+2:51]>>[F:1][c:2]1[c:3](-[c:20]2[c:21]([C:26]([CH3:27])=[O:28])[cH:22][cH:23][cH:24][cH:25]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

11

Reactant 10

HCID 175Acetate2×HCID 259Bromide ionHCID 813Potassium Cation2×HCID 962WaterHCID 8857Ethyl AcetateHCID 16028TetrabutylammoniumHCID 19660Carbonate IonHCID 750602'-BromoacetophenoneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27343342,4-Difluorophenylboronic acid

Product 1

HCID 224822721-(2',4'-Difluoro-1,1'-biphenyl-2-yl)ethanone

Sources & evidence

ORD record
ord-1844c6bf634c4fe7a04a4bee5ad199b0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

Loading…