1-Chloro-2-fluoro-4-iodo-5-methoxybenzene → (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone

HRID 30145

Reaction equation

HRID 30145 reaction equation
[NH2:1][C:2]1[N:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[Cl:15][C:16]1[C:17]([F:25])=[CH:18][C:19](I)=[C:20]([O:22][CH3:23])[CH:21]=1>>[NH2:1][C:2]1[C:3]([C:4]([C:19]2[CH:18]=[C:17]([F:25])[C:16]([Cl:15])=[CH:21][C:20]=2[O:22][CH3:23])=[O:5])=[CH:10][CH:11]=[C:12]([Cl:14])[N:13]=1

Participants

3

Reactant 2

HCID 210706301-Chloro-2-fluoro-4-iodo-5-methoxybenzeneHCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

Product 1

HCID 58590823(2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone

Procedure

The title compound was prepared from 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide (Example 3) and 5-chloro-4-fluoro-2-iodoanisole (prepared as described in Step A above) using the procedure described in Example 7. HRMS, observed: 312.9943, Calcd for (M−H)+: 312.9947.

Sources & evidence

ORD record
ord-8b2ab23d421d4ca7b820de3c492a45e2
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Linked notes

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