Bromomethylcyclopropane → 1-(3-Chloro-benzyl)-2-(4-chloro-2-cyclopropylmethoxy-phenyl)-5,6-difluoro-1H-benzoimidazole

Reaction equation

[Br:28][CH2:29][CH:30]1[CH2:31][CH2:32]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:9]2[n:10][c:11]3[c:12]([n:13]2[CH2:14][c:15]2[cH:16][c:17]([Cl:21])[cH:18][cH:19][cH:20]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[c:6]([OH:8])[cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:9]2[n:10][c:11]3[c:12]([n:13]2[CH2:14][c:15]2[cH:16][c:17]([Cl:21])[cH:18][cH:19][cH:20]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[c:6]([O:8][CH2:29][CH:30]2[CH2:31][CH2:32]2)[cH:7]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 1363784805-chloro-2-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol

Product 1

HCID 582092851-(3-Chloro-benzyl)-2-(4-chloro-2-cyclopropylmethoxy-phenyl)-5,6-difluoro-1H-benzoimidazole

Sources & evidence

ORD record: ord-202b357112a143fc98ac4791229a95ea
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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