Dichloromethane → 4-[2-(Trifluoromethyl)phenoxy]piperidine

HRID 303436

Reaction equation

HRID 303436 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:32][CH2:33][Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 46941590Tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate

Product 1

HCID 50187904-[2-(Trifluoromethyl)phenoxy]piperidine

Sources & evidence

ORD record
ord-7cfdb9176d9f46b095085645055abc50
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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