Hydrochloric Acid → Ethanamine, 2-(4-fluorophenoxy)-, hydrochloride (1:1)

HRID 30537

Reaction equation

C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[F:17][C:14]1[CH:15]=[CH:16][C:11]([O:10][CH2:9][CH2:8][NH2:7])=[CH:12][CH:13]=1

Participants

Conditions

Temperature: 0 °C

Procedure

Next, to a solution of [2-(4-fluorophenoxy)ethyl]carbamic acid tert-butyl ester (7.0 g, 27.4 mmol) in dioxane (20 mL) cooled in an ice bath was added 4N—HCl in dioxane (100 mL) dropwise. The mixture was stirred at 0° C. for 2 hours, and at room temperature for 16 hours. The precipitates were filtered, washed with diethylether, and dried under reduced pressure to yield 2-(4-fluorophenoxy)ethylamine HCl salt (4.24 g, 80.7% yield).

Workup

waitat room temperature for 16 hours
filtrationThe precipitates were filtered
washwashed with diethylether
customdried under reduced pressure

Sources & evidence

ORD record: ord-54903767278b4fbbaa8fd42caec3bb42
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423175B2

Linked notes

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