Water → N-[5-(5-Cyanopyridin-3-ylethynyl)-2-fluorophenyl]-acetamide

HRID 305573

Reaction equation

HRID 305573 reaction equation
[CH3:19][C:20]([Cl:21])=[O:22].[NH2:1][c:2]1[cH:3][c:4]([C:9]#[C:10][c:11]2[cH:12][n:13][cH:14][c:15]([C:16]#[N:17])[cH:18]2)[cH:5][cH:6][c:7]1[F:8].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1.[OH2:34].[cH:23]1[cH:24][cH:25][n:26][cH:27][cH:28]1>>[NH:1]([c:2]1[cH:3][c:4]([C:9]#[C:10][c:11]2[cH:12][n:13][cH:14][c:15]([C:16]#[N:17])[cH:18]2)[cH:5][cH:6][c:7]1[F:8])[C:20]([CH3:19])=[O:22]

Participants

6

Reactant 5

HCID 962WaterHCID 1049PyridineHCID 6367Acetyl chlorideHCID 8028TetrahydrofuranHCID 670478225-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile

Product 1

HCID 67048361N-[5-(5-Cyanopyridin-3-ylethynyl)-2-fluorophenyl]-acetamide

Sources & evidence

ORD record
ord-dba7af453ec04b59b945ae21015487ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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