Tetrahydrofuran → 6-(2,6-Difluorophenyl)pyridin-3-amine

HRID 306210

Reaction equation

HRID 306210 reaction equation
[Br:14][c:15]1[cH:16][cH:17][c:18]([NH2:21])[cH:19][n:20]1.[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:9][CH2:10][CH2:11][CH2:12][Li:13].[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([F:7])[cH:8]1.[cH:27]1[cH:28][cH:29][c:30]([P:31]([Pd:32]([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)([P:52]([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[P:71]([c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[cH:102][cH:103]1>>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([F:7])[c:8]1-[c:15]1[cH:16][cH:17][c:18]([NH2:21])[cH:19][n:20]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 97411,3-DifluorobenzeneHCID 6428116-Bromopyridin-3-amineHCID 178418339ButyllithiumHCID 178420554HCID 178420554, compound

Product 1

HCID 584158756-(2,6-Difluorophenyl)pyridin-3-amine

Sources & evidence

ORD record
ord-88c067e7149a41a785e89a295d374c64
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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