Methylamine → 1-Isobutyl-3-methylthiourea

HRID 31064

Reaction equation

HRID 31064 reaction equation
[CH3:1][NH2:2].[CH2:3]([N:7]=[C:8]=[S:9])[CH:4]([CH3:6])[CH3:5]>>[CH2:3]([NH:7][C:8]([NH:2][CH3:1])=[S:9])[CH:4]([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 68960Isobutyl isothiocyanate

Product 1

HCID 155682431-Isobutyl-3-methylthioureaYield 98.2%

Procedure

Methylamine (2M in methanol, 20.0 mL, 40.2 mmol) was added dropwise to isobutylisothiocyanate (2.00 mL, 16.5 mmol) during 15 minutes at room temperature. The reaction mixture was heated to reflux for 3.5 h and the solvent was evaporated off to give the title compound (2.37 g, 98%) as a colourless oil.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 3.5 h
  3. customthe solvent was evaporated off

Sources & evidence

ORD record
ord-daba692c6a114204a87d5a67bd05525c
Source dataset
uspto-grants-2008_09
Patent number
US07425560B2

Linked notes

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