2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazole → HCID 58629794, compound

HRID 31461

Reaction equation

HRID 31461 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][CH:3]=1.[CH3:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([C:24]2[CH:28]=[CH:27][S:26][CH:25]=2)=[O:23])=[CH:17][C:16]=1B1OC(C)(C)C(C)(C)O1>CC(O)C>[CH3:14][C:15]1[C:16]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([CH3:13])=[N:11][N:12]=3)=[CH:4][CH:3]=2)=[CH:17][C:18]([NH:21][C:22]([C:24]2[CH:28]=[CH:27][S:26][CH:25]=2)=[O:23])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 6765692-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazole2×HCID 21914662N-[4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-thiophenecarboxamide2×

Product 1

HCID 58629794HCID 58629794, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Example 34 was prepared using 2-(4-iodophenyl)-5-methyl-[1,3,4]oxadiazole (Intermediate 15) and N-[4-methyl-3-(4,4,5,5, -tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]thiophene-3-amide (Intermediate 27) with propan-2-ol as the solvent.

Workup

  1. customExample 34 was prepared

Sources & evidence

ORD record
ord-a1347c86e2fb4e1fb11912cdbd0957d3
Source dataset
uspto-grants-2008_09
Patent number
US07425555B2

Linked notes

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