Dichloromethane → 4-Fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzoic acid

HRID 315428

Reaction equation

[CH2:26]([SiH:27]([CH2:28][CH3:29])[CH2:30][CH3:31])[CH3:32].[CH2:33]([Cl:34])[Cl:35].[NH2:15][c:16]1[cH:17][c:18]([C:19](=[O:20])[OH:21])[cH:22][cH:23][c:24]1[F:25].[n:1]1[c:2]([NH:7][c:8]2[s:9][c:10]([CH:13]=[O:14])[cH:11][n:12]2)[cH:3][cH:4][cH:5][cH:6]1>>[n:1]1[c:2]([NH:7][c:8]2[s:9][c:10]([CH2:13][NH:15][c:16]3[cH:17][c:18]([C:19](=[O:20])[OH:21])[cH:22][cH:23][c:24]3[F:25])[cH:11][n:12]2)[cH:3][cH:4][cH:5][cH:6]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 12052Triethylsilane

HCID 753963-Amino-4-fluorobenzoic acid

HCID 220190582-(Pyridin-2-ylamino)thiazole-5-carbaldehyde

Product 1

HCID 220190564-Fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzoic acid

Sources & evidence

ORD record: ord-479a017d1afd44b79be8b1667bb5c741
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Linked notes

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