Toluene → Tert-butyl 3-(6-nitro-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

HRID 315465

Reaction equation

HRID 315465 reaction equation
[Br:16][c:17]1[cH:18][cH:19][c:20]([N+:23](=[O:24])[O-:25])[n:21][cH:22]1.[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[CH:1]12[CH2:2][NH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[N:8]2[C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15]>>[CH:1]12[CH2:2][N:3]([c:17]3[cH:18][cH:19][c:20]([N+:23](=[O:24])[O-:25])[n:21][cH:22]3)[CH2:4][CH:5]([CH2:6][CH2:7]1)[N:8]2[C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15]

Participants

5

Reactant 4

HCID 1140TolueneHCID 8471TriethylamineHCID 8176205-Bromo-2-nitropyridineHCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octane

Product 1

HCID 67356030Tert-butyl 3-(6-nitro-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

Sources & evidence

ORD record
ord-f67c891f1599472092840dfcbba2159b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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