Water → 1-{[4-Chloro-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine

Reaction equation

[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[Cl:1][c:2]1[cH:3][c:4]([C:25]([F:26])([F:27])[F:28])[c:5]([CH2:8][n:9]2[n:10][c:11]([N:14]3[C:15](=[O:16])[c:17]4[c:18]([cH:19][cH:20][cH:21][cH:22]4)[C:23]3=[O:24])[cH:12][cH:13]2)[cH:6][cH:7]1.[NH2:30][NH2:31].[OH2:29]>>[Cl:1][c:2]1[cH:3][c:4]([C:25]([F:26])([F:27])[F:28])[c:5]([CH2:8][n:9]2[n:10][c:11]([NH2:14])[cH:12][cH:13]2)[cH:6][cH:7]1

Participants

Reactant 4

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 9321Hydrazine

HCID 667707212-(1-{[4-chloro-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione

Product 1

HCID 595478701-{[4-Chloro-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine

Sources & evidence

ORD record: ord-48182d60ac7b40ae8dfbcef2314baad9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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