Ethyl ketone → (2,2-Diethyl-1,3-dioxan-5-yl)methanol

Reaction equation

[OH:1][CH2:2][CH:3]([CH2:6][OH:7])[CH2:4][OH:5].[CH3:8][CH2:9][C:10](=O)[CH2:11][CH3:12]>>[CH2:9]([C:10]1([CH2:11][CH3:12])[O:5][CH2:4][CH:3]([CH2:6][OH:7])[CH2:2][O:1]1)[CH3:8]

Participants

Reactant 2

HCID 7288Ethyl ketone

HCID 78432Trimethylolmethane

Product 1

HCID 14629254(2,2-Diethyl-1,3-dioxan-5-yl)methanolYield 46%

Procedure

The same procedure as in the step (7a) of Example 7 was repeated using 2-(hydroxymethyl)-1,3-propanediol, and 3-pentanone to obtain the title compound (1.5 g, yield: 46%) as a light yellow oil.

Sources & evidence

ORD record: ord-df690b281915412e85a8cfc989c8363c
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07425634B2

Reaction notes

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