Hydrochloric Acid → 2-Bromo-1-(4-ethylphenyl)ethan-1-one
Reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1)[CH3:2].Cl.[Br:13]Br>C(OCC)C.C(Cl)(Cl)Cl>[Br:13][CH2:10][C:9]([C:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=1)=[O:11]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
20 mmol of 1-(4-ethylphenyl)ethan-1-one, 1 ml conc. HCl were mixed in 20 ml diethyl ether at 0° C. under nitrogen. To this solution a solution of 20 mmol Br2 in 20 ml chloroform was added drop wise and left for four hours and then concentrated in vacuo to obtain 2-bromo-1-(4-ethylphenyl)ethan-1-one.
Workup
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-5692d5c2f3444ebc83f4eb8ca1d733a9
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07425557B2
Reaction notes
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