Ethylenediamine → 2,6-Diamino-N2-(2-aminoethyl)-5-nitropyridine

HRID 31847

Reaction equation

HRID 31847 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH2:12][CH2:13][CH2:14][NH2:15].[OH-].[Na+]>O>[NH2:12][CH2:13][CH2:14][NH:15][C:4]1[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([NH2:1])[N:3]=1

Participants

5

Reactant 3

HCID 3301EthylenediamineHCID 14798Sodium HydroxideHCID 27240356-Chloro-3-nitropyridin-2-ylamine

Product 1

HCID 221423802,6-Diamino-N2-(2-aminoethyl)-5-nitropyridine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 mmol of 2-amino-6-chloro-3-nitropyridine and 15 mmol of 1,2-diaminoethane were stirred at reflux for fourteen hours. The reaction mixture was concentrated in vacuo and solution of 1.5 mmol of NaOH in water was added. This solution was extracted twice with 95%/5% methylene chloride/methanol. The aqueous was then saturated with salt and extracted twice with 95%/5% acetonitrile/methanol and then finally extrated twice with 95%/5% ethylacetate/methanol. All organic fractions were combined and dried over sodium sulfate to obtain (2-aminoethyl)(6-amino-5-nitro(2-pyridyl))amine.

Workup

  1. temperatureat reflux for fourteen hours
  2. additionwas added
  3. extractionThis solution was extracted twice with 95%/5% methylene chloride/methanol
  4. extractionsaturated with salt and extracted twice with 95%/5% acetonitrile/methanol
  5. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-92d0d0ce25ff48e1be007eecd5189581
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Linked notes

Loading…