Dichloromethane → N-[2-[4-[[9-[(4-fluorophenyl)methyl]purin-8-yl]amino]piperidin-1-yl]ethyl]furan-3-carboxamide

HRID 319130Notes

Reaction equation

HRID 319130 reaction equation
[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[Cl:10][c:11]1[cH:12][cH:13][cH:14][cH:15][n+:16]1[CH3:17].[Cl:52][CH2:53][Cl:54].[I-:9].[NH2:25][CH2:26][CH2:27][N:28]1[CH2:29][CH2:30][CH:31]([NH:34][c:35]2[n:36]([CH2:44][c:45]3[cH:46][cH:47][c:48]([F:51])[cH:49][cH:50]3)[c:37]3[n:38][cH:39][n:40][cH:41][c:42]3[n:43]2)[CH2:32][CH2:33]1.[o:1]1[cH:2][c:3]([C:6](=[O:7])[OH:8])[cH:4][cH:5]1>>[o:1]1[cH:2][c:3]([C:6](=[O:8])[NH:25][CH2:26][CH2:27][N:28]2[CH2:29][CH2:30][CH:31]([NH:34][c:35]3[n:36]([CH2:44][c:45]4[cH:46][cH:47][c:48]([F:51])[cH:49][cH:50]4)[c:37]4[n:38][cH:39][n:40][cH:41][c:42]4[n:43]3)[CH2:32][CH2:33]2)[cH:4][cH:5]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 102683-Furoic acidHCID 30165Iodide IonHCID 1670702-Chloro-1-methylpyridiniumHCID 19785318N-[1-(2-aminoethyl)-4-piperidinyl]-9-[(4-fluorophenyl)methyl]-9H-purin-8-amine

Product 1

HCID 19785249N-[2-[4-[[9-[(4-fluorophenyl)methyl]purin-8-yl]amino]piperidin-1-yl]ethyl]furan-3-carboxamide

Sources & evidence

ORD record
ord-46a96de1e13146d3b2135e7bc1b844b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…