Sodium ion → 6-[3-(2-tert-butoxycarbonylamino-2-methyl-propyl)-1H-indol-7-yloxy]-nicotinic acid methyl ester

HRID 319920

Reaction equation

HRID 319920 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]([CH2:9][c:10]1[cH:11][nH:12][c:13]2[c:14]([OH:19])[cH:15][cH:16][cH:17][c:18]12)([CH3:20])[CH3:21])=[O:22].[CH3:25][O:26][C:27]([c:28]1[cH:29][n:30][c:31]([Cl:34])[cH:32][cH:33]1)=[O:35].[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[H-:23].[Na+:24].[OH2:36]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]([CH2:9][c:10]1[cH:11][nH:12][c:13]2[c:14]([O:19][c:31]3[n:30][cH:29][c:28]([C:27]([O:26][CH3:25])=[O:35])[cH:33][cH:32]3)[cH:15][cH:16][cH:17][c:18]12)([CH3:20])[CH3:21])=[O:22]

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 166653HydrideHCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 69519112[2-(7-hydroxy-1H-indol-3-yl)-1,1-dimethyl-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 695167856-[3-(2-tert-butoxycarbonylamino-2-methyl-propyl)-1H-indol-7-yloxy]-nicotinic acid methyl ester

Sources & evidence

ORD record
ord-dd364f238c84488e882d98910c0331ed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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