Acetic Anhydride → Cyanoacetyldibenzylurea

HRID 322570

Reaction equation

HRID 322570 reaction equation
[CH2:1]([NH:8][C:9]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]([CH2:21][C:22](O)=[O:23])#[N:20].C(OC(=O)C)(=O)C>O>[C:19]([CH2:21][C:22]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:9]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])=[O:23])#[N:20]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 9740Cyanoacetic acidHCID 72889Urea, N,N'-bis(phenylmethyl)-

Product 1

HCID 20642783Cyanoacetyldibenzylurea

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

36.0 g (0.15 mol) of dibenzylurea, 15.3 g (0.18 mol) of cyanoacetic acid and 30.6 g (0.3 mol) of acetic anhydride are stirred at 80-85° C. for 2 hours. After cooling, the reaction mixture is stirred into 600 ml of water and the resultant precipitate is filtered off with suction and then dried to constant weight.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resultant precipitate is filtered off with suction
  3. customdried to constant weight

Sources & evidence

ORD record
ord-c240c421fc754ef49d6d0795e73d913e
Source dataset
uspto-grants-2001_04
Patent number
US06211270B1

Linked notes

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