Methylamine → 7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-one

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15](=[O:16])[C:10]3[N:11]=[C:12]([CH3:14])O[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:17]=1.[CH3:18][NH2:19]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15](=[O:16])[C:10]3[N:11]=[C:12]([CH3:14])[N:19]([CH3:18])[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:17]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 220036227-Chloro-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-one

Product 1

HCID 220035787-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-one

Conditions

Temperature: 40 °C

Procedure

A mixture of the product from step (i) (3.33 g), and 40% w/v aqueous methylamine solution was heated at 40° C. for 4 h. The solid was filtered and washed with water then dried under vacuum to give the subtitled product as a cream powder.

Workup

filtrationThe solid was filtered
washwashed with water
customthen dried under vacuum

Sources & evidence

ORD record: ord-0f6c87ceb3174547afec6071ffdae44c
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06218376B1

Reaction notes

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