2-Propanone, 1-(3,4-dimethoxyphenyl)- → 3,4-Dma, (R)-

HRID 324949

Reaction equation

C(O)[C:2]([NH2:7])([CH2:5]O)[CH2:3]O.Cl.[CH3:10][O:11][C:12]1[CH:13]=[C:14](CC(=O)C)[CH:15]=[CH:16][C:17]=1[O:18][CH3:19].C1([C@H](N)C)C=CC=CC=1>>[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH2:5][C@H:2]([NH2:7])[CH3:3])[CH:15]=[CH:16][C:17]=1[O:18][CH3:19]

Participants

Reactant 3

HCID 698962-Propanone, 1-(3,4-dimethoxyphenyl)-

HCID 93573Tromethamine hydrochloride

HCID 6431891-Phenethylamine, (+)-

Product 1

HCID 117694083,4-Dma, (R)-

Procedure

Using 10 ml of the cell-free extract, the components were reacted in 100 ml of a reaction mixture comprising a 0.1 M Tris-hydrochloric acid buffer (pH 8.5) containing 0.5 g of 1-(3,4-dimethoxyphenyl)-2-propanone and 0.34 g of (R)-1-phenylethylamine at 30° C. for 24 hours. As a result, 0.36 g of (R)-(3,4-dimethoxyphenyl)-2-aminopropane was formed.

Workup

extractionextract
customthe components were reacted in 100 ml of a reaction mixture

Sources & evidence

ORD record: ord-457daacc5991415ab694fef18f9be7de
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06221638B1

Linked notes

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