Hydrochloric Acid → Enoxacin hydrochloride

HRID 325614

Reaction equation

HRID 325614 reaction equation
[CH3:1][CH2:2][N:3]1[C:9]2[N:10]=[C:11]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1.[ClH:24]>>[CH3:1][CH2:2][N:3]1[C:9]2[N:10]=[C:11]([N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1.[ClH:24]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 3229Enoxacin

Product 1

HCID 12901163Enoxacin hydrochloride

Procedure

The anhydrous AT-2266 prepared by Reference Example 2 or the AT-2266.trihydrate prepared by Reference Example 3 was dissolved in 5% hydrochloric acid and the solution was concentrated to dryness under reduced pressure. The residue was recrystallized from water to give the AT-2266.hydrochloride, mp above 300° C. (dec.).

Workup

  1. concentrationthe solution was concentrated to dryness under reduced pressure
  2. customThe residue was recrystallized from water

Sources & evidence

ORD record
ord-118b83e619ae4bc79b78fd600e7791e7
Source dataset
uspto-grants-1984_04
Patent number
US04442101

Linked notes

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