Hydrochloric Acid → 5-(chloromethyl)pyrimidine-2,4(1h,3h)-dione

HRID 325770

Reaction equation

HRID 325770 reaction equation
O[CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[ClH:11]>>[Cl:11][CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 781685-(Hydroxymethyl)uracil

Product 1

HCID 2361255-(chloromethyl)pyrimidine-2,4(1h,3h)-dione

Procedure

A solution of 1.4 g. (0.010 mole) of 5-hydroxymethyl uracil in 12.5 ml. of concentrated hydrochloric acid was prepared. A colorless precipitate (5-chloromethyl uracil) formed within two minutes and after about ten minutes the precipitate was collected by filtration, washed rapidly with ice cold water, dried and then suspended in 10 ml. of dimethylformamide.

Sources & evidence

ORD record
ord-6b035761cb7c49199778fff3e1e35582
Source dataset
uspto-grants-1984_04
Patent number
US04442290

Linked notes

Loading…