1-Propanone, 3-(dimethylamino)-1-phenyl-, hydrochloride (1:1) → 3-(Dimethylamino)-1-phenyl-1-propanone

HRID 326399

Reaction equation

HRID 326399 reaction equation
Cl.[CH3:2][N:3]([CH3:14])[CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7].C(=O)(O)[O-].[Na+]>ClCCl>[CH3:14][N:3]([CH3:2])[CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7]

Participants

4

Reactant 2

HCID 928441-Propanone, 3-(dimethylamino)-1-phenyl-, hydrochloride (1:1)HCID 516892Sodium Bicarbonate

Product 1

HCID 770423-(Dimethylamino)-1-phenyl-1-propanoneYield 95.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Dimethylaminopropiophenone hydrochloride (20 g) was treated with aqueous sodium bicarbonate solution in dichloromethane. The layers were separated and the organic phase was dried over anhydrous magnesium sulfate, filtered, and the filtrate was evaporated to provide 15.8 g of 3-dimethylaminopropiophenone.

Workup

  1. customThe layers were separated
  2. dry with materialthe organic phase was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-8405d6c06e7a480280c47c4f322f1fd8
Source dataset
uspto-grants-1993_12
Patent number
US05268468

Linked notes

Loading…