Pyrrolidine → 5-(Propane-1-sulfonyl)-2-pyrrolidin-1-yl-benzoic acid

HRID 32678

Reaction equation

HRID 32678 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].Cl[C:20]1C=CC(S(C(C)C)(=O)=O)=C[C:21]=1C(O)=O.N1CCCC1>>[CH2:1]([S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3])[CH2:20][CH3:21]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 431409992-Chloro-5-(propane-2-sulfonyl)benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 597936365-(Propane-1-sulfonyl)-2-pyrrolidin-1-yl-benzoic acidYield 63%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(propane-2-sulfonyl)-benzoic acid and pyrrolidine and obtained in 63% yield. MS (m/e): 296.2 (MH−, 100%).

Workup

  1. customobtained in 63% yield

Sources & evidence

ORD record
ord-790179f33c32489cb60f0cda3d50b17c
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Linked notes

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