Pyrrolidine → 5-Methylsulfamoyl-2-pyrrolidin-1-yl-benzoic acid

HRID 32680Notes

Reaction equation

HRID 32680 reaction equation
C[S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].ClC1C=CC(S(=O)(=O)[NH:30][CH3:31])=CC=1C(O)=O.N1CCCC1>>[CH3:31][NH:30][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 453196905-Methylsulfamoyl-2-pyrrolidin-1-yl-benzoic acidYield 45%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-methylsulfamoyl-benzoic acid and pyrrolidine and obtained in 45% yield. MS (m/e): 283.1 (MH−, 100%).

Workup

  1. customobtained in 45% yield

Sources & evidence

ORD record
ord-bbb1ed821a6b463981f879e6ce7730ea
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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