4-Piperidone → N-(4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine

HRID 326810

Reaction equation

HRID 326810 reaction equation
[NH2:1][C:2]([CH3:9])([CH3:8])[CH2:3][NH:4][CH2:5][CH2:6][NH2:7].[NH:10]1[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]1>>[NH:10]1[CH2:15][CH2:14][CH:13]([NH:7][CH2:6][CH2:5][NH:4][CH2:3][C:2]([NH2:1])([CH3:9])[CH3:8])[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 337214-PiperidoneHCID 10898752N,N'-(2-amino-2-methylpropyl)ethylenediamine

Product 1

HCID 19736233N-(4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine

Procedure

In a manner analogous to that described immediately hereinabove, by reacting N-(2-amino-2-methylpropyl)-1,2-ethanediamine with piperidin-4-one, it is reductively alkylated to yield N-(4-piperidyl)-N'-(2-amino-2-methyl-propyl)-1,2-ethanediamine; and, 2,2,6,6-piperidin-4-one is reductively alkylated to yield N-(2,2,6,6-tetramethyl-4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine having the structure: ##STR15##

Sources & evidence

ORD record
ord-f60808e2c46e4c61b6f76bcf318f4c83
Source dataset
uspto-grants-1993_12
Patent number
US05270471

Linked notes

Loading…