19-Hydroxytestosterone → HCID 22849351, compound

HRID 326983

Reaction equation

HRID 326983 reaction equation
[CH3:1][C@@:2]12[C@@H:10]([OH:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH2:13][C:14]3[C@@:20]([CH2:21][OH:22])([C@H:5]1[CH2:4][CH2:3]2)[CH2:19][CH2:18][C:16](=[O:17])[CH:15]=3.OC[C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C(=O)CC4)CCC1=CC(=O)CC2.[BH4-].[K+]>C(O)C>[CH3:1][C@:2]12[CH2:3][CH2:4][C@H:5]3[C@@H:6]([CH2:12][CH2:13][C:14]4[C@:20]3([CH2:21][OH:22])[CH2:19][CH2:18][C:16](=[O:17])[CH:15]=4)[C@@H:7]1[CH2:8][CH2:9][CH:10]2[OH:11]

Participants

5

Reactant 3

HCID 15096819-HydroxytestosteroneHCID 25237919-HydroxyandrostenedioneHCID 4192641Potassium borohydride

Product 1

HCID 22849351HCID 22849351, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Also known as 19-Hydroxytestosterone, this compound is commercially available from Steraloids, Inc. Alternatively, 19-hydroxyandrost-4-en-3,17-dione (11) is treated with potassium borohydride (KBH4, a) in ethanol at -10° to 0° C. Aqueous work up is followed by extraction and purification to yield 19-hydroxytestosterone (12).

Workup

  1. customat -10° to 0° C
  2. extractionAqueous work up is followed by extraction and purification

Sources & evidence

ORD record
ord-90602cc878724a59a9a209d969e464c5
Source dataset
uspto-grants-1993_12
Patent number
US05272134

Linked notes

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