Hydrochloric Acid → 3-amino-4-methyl-pentan-2-one
Reaction equation
C([NH:4][CH:5]([CH:9]([CH3:11])[CH3:10])[C:6](=[O:8])[CH3:7])(=O)C.[ClH:12]>C(O)C>[ClH:12].[O:8]=[C:6]([CH:5]([NH2:4])[CH:9]([CH3:11])[CH3:10])[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-acetyl-2-keto-3-amino-4-methylpentane (6.33 g, 40.3 mmol) and 6M hydrochloric acid (65 ml) was heated at reflux overnight. The reaction mixture was cooled to room temperature, ethanol (100 ml) was added and the mixture concentrated under reduced pressure. The mixture was triturated with ether to give a precipitate which was collected by filtration. Crystallisation from acetone gave 2-keto-3-amino-4-methylpentane hydrochloride (2.9 g, 63%) as a white crystalline solid.
Workup
- temperaturewas heated
- temperatureat reflux overnight
- concentrationthe mixture concentrated under reduced pressure
- customThe mixture was triturated with ether
- customto give a precipitate which
- filtrationwas collected by filtration
- customCrystallisation from acetone
Sources & evidence
- ORD record
- ord-cedb8de6facd4d2cb277e55f0f74b1f2
- Source dataset
- uspto-grants-1993_12
- Patent number
- US05274094
Reaction notes
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