hydroxylamine-O-sulfonic acid → 1-Amino-3-benzoylpyrrole

HRID 327814

Reaction equation

HRID 327814 reaction equation
[C:1]([C:9]1[CH:13]=[CH:12][NH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:14]OS(O)(=O)=O>[OH-].[K+]>[NH2:14][N:11]1[CH:12]=[CH:13][C:9]([C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:10]1

Participants

4

Reactant 2

HCID 76284hydroxylamine-O-sulfonic acidHCID 27732343-Benzoylpyrrole

Product 1

HCID 199731561-Amino-3-benzoylpyrrole

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

A 3-benzoylpyrrole of the formula ##STR25## in potassium hydroxide or other suitable base is reacted with hydroxylamine-O-sulfonic acid to yield a 1-amino-3-benzoylpyrrole of the formula ##STR26## This reaction typically takes place in the presence of a suitable solvent such as dimethylformamide at a temperature of about 0° to 25° C. (or at room temperature) for 0.5 to 4 hours.

Sources & evidence

ORD record
ord-5254461ba2fb43b3bbf05656f276599b
Source dataset
uspto-grants-1993_12
Patent number
US05274116

Linked notes

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