Ammonium Hydroxide → 1-(2-Amino-1,3-thiazol-4-yl)ethan-1-one

1-(2-Amino-thiazol-4-yl)-ethanone hydrochloride (5.6 g 29.1 mmol) was dissolved in water (15 mL) and cooled in an ice bath. To this was added dropwise 17 N ammonium hydroxide (15 mL, 105 mmol). The resulting mixture was stirred for 15 minutes than filtered and washed with cold water (3×), cold methanol (3×50 mL), ethyl ether (3×10 mL). The precipitate was dried first by passing air through the material and then in vacuo to give 1-(2-amino-thiazol-4-yl)-ethanone as a pale yellow solid (2.6 g, 57%).

1. temperaturecooled in an ice bath
2. filtrationthan filtered
3. washwashed with cold water (3×), cold methanol (3×50 mL), ethyl ether (3×10 mL)
4. customThe precipitate was dried first

ORD record

ord-20db3dd31de543458c8215a5f7af857c

Source dataset

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07427635B2