Hydrogen iodide → 2-(4-Hydroxyphenyl)propionic acid
Reaction equation
[N+]([C:4]1[CH:5]=[C:6]([CH:11]([CH3:15])[C:12]([O-:14])=[O:13])[CH:7]=[CH:8][C:9]=1[OH:10])([O-])=O.COC1C=CC(C(C)C(O)=O)=CC=1.I>>[OH:10][C:9]1[CH:4]=[CH:5][C:6]([CH:11]([CH3:15])[C:12]([OH:14])=[O:13])=[CH:7][CH:8]=1Participants
4
Procedure
Also, the compounds (III) used for this invention, for example, 2-(3-nitro-4-hydroxyphenyl)propionate can be prepared by demethylating 2-(4-methoxyphenyl)propionic acid with hydroiodic acid and the like to obtain 2-(4-hydroxyphenyl)- propionic acid, by esterifying the above compound with an usual method to obtain, for example, methyl 2-(4-hydroxyphenyl)propionate and by nitrating the above compounds. Alternately, 2-(3-nitro-4-hydroxyphenyl)propionate can be prepared by nitrating the above 2-(4-hydroxyphenyl)propionic acid with an usual method and by esterificating the resultant compound. The above reactions can be applied to 4-hydroxyphenylacetate as well. The above reaction scheme is shown as follows: ##STR12## wherein R1 has the same meaning as above