HCID 7078333, compound → HCID 53801005, compound
Reaction equation
[C@@H:1]1([N:10]2[CH:18]=[C:16]([CH3:17])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[O:7][C@H:6]([CH2:8][OH:9])[C@H:4]([OH:5])[C@H:2]1[OH:3]>O.[Rh]>[CH3:17][CH:16]1[CH2:18][N:10]([C@@H:1]2[O:7][C@H:6]([CH2:8][OH:9])[C@H:4]([OH:5])[C@H:2]2[OH:3])[C:11](=[O:12])[NH:13][CH:14]1[OH:15].[CH3:17][CH:16]1[CH2:18][N:10]([C@@H:1]2[O:7][C@H:6]([CH2:8][OH:9])[C@H:4]([OH:5])[C@H:2]2[OH:3])[C:11](=[O:12])[NH:13][CH2:14]1Participants
5
Reactant 1
Product 2
Reagents, catalysts & solvents 2
Procedure
In the manner given in Example 2D, 1-β-D-xylofuranosylthymine [Fox et al., J. Am. Chem. Soc. 80, 5155 (1958)] was hydrogenated in ammoniacal water in the presence of a rhodium on alumina catalyst to give 5-methyl-4-hydroxy-1-β-D-xylofuranosyl-tetrahydro-2(1H)-pyrimidinone and 5-methyl-1-β-D-xylofuranosyl-tetrahydro-2(1H)-pyrimidinone.