2-Methyl-4-amino-5-aminomethylpyrimidine carbonate → 4-Amino-2-methyl-5-pyrimidinemethanamine

HRID 329762

Reaction equation

C(=O)(O)O.[CH3:5][C:6]1[N:11]=[C:10]([NH2:12])[C:9]([CH2:13][NH2:14])=[CH:8][N:7]=1>C(O)(C)C>[CH3:5][C:6]1[N:11]=[C:10]([NH2:12])[C:9]([CH2:13][NH2:14])=[CH:8][N:7]=1

Participants

Conditions

Temperature: 85 °C

Procedure

An amount of 170 g of isopropanol was added to 30.0 g of the 2-methyl-4-amino-5-aminomethylpyrimidine carbonate thus obtained, followed by heating at about 85° C. for 180 minutes to give 2-methyl-4-amino-5-aminomethylpyrimidine with purity of 99.0%.

Workup

customthus obtained

Sources & evidence

ORD record: ord-daebf62d6a7d48fa849fe817df70603a
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04892948

Linked notes

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