2-Propanethiol → HCID 19868700, compound

HRID 330503

Reaction equation

HRID 330503 reaction equation
[OH:1][CH:2]1[NH:6][C:5](=O)[CH2:4][CH2:3]1.[CH3:8][CH:9]([SH:11])[CH3:10]>CCOCC>[CH:9]([S:11][CH:5]1[NH:6][C:2](=[O:1])[CH2:3][CH2:4]1)([CH3:10])[CH3:8]

Participants

4

Reactant 2

HCID 63642-PropanethiolHCID 1941485-Hydroxy-2-pyrrolidone

Product 1

HCID 19868700HCID 19868700, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 9 g of 5-hydroxy-pyrrolidin-2-one in 40 cm3 of 2-propanethiol and 5 g of Amberlite resin IR 120 H is maintained for 80 hours at ambient temperature. After diluting with ether, filtering, and concentrating under reduced pressure, 8.5 g of the expected product is obtained. m.p. 77°-79° C., crystallized from isopropyl ether. m.p. 85°-87° C. after re-crystallization.

Workup

  1. filtrationfiltering
  2. concentrationconcentrating under reduced pressure

Sources & evidence

ORD record
ord-305946d9a6094476881ff00344e5235f
Source dataset
uspto-grants-1990_01
Patent number
US04897414

Linked notes

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