Hydrochloric Acid → 6-Chloro-2-piperazin-1-yl-quinoline hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([Cl:24])[CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:24].[Cl:24][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][CH:18]=1)[N:15]=[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH:23]=[CH:22]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared in analogy to example 1.6(d) from 4-(6-chloro-quinolin-2-yl)-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid.
Sources & evidence
- ORD record
- ord-84c047b4b2554a3b8098263785abf800
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07429585B2
Reaction notes
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