Magnesium chloride hexahydrate → Vildagliptin Magnesium(II)-Chloride

HRID 332076

Reaction equation

HRID 332076 reaction equation
O.O.O.O.O.O.[Cl-:7].[Mg+2:8].[Cl-].[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:27][CH:21]([CH2:22][CH:23]([CH2:25]4)[CH2:24]2)[CH2:20]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1>CC(O)C>[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:25][CH:23]([CH2:22][CH:21]([CH2:27]4)[CH2:20]2)[CH2:24]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1.[Cl-:7].[Mg+2:8].[Cl-:7]

Participants

4

Reactant 2

HCID 24644Magnesium chloride hexahydrateHCID 6918537Vildagliptin

Product 1

HCID 86675510Vildagliptin Magnesium(II)-Chloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.34 g (1.65 mmole) of magnesium(II)-chloride hexahydrate is dissolved in 15 cm3 of 2-propanol at 50° C. under intensive stirring, and 1.0 g (3.3 mmole) of vildagliptin base is added to the solution. The solution is stirred at room temperature for 2 hours and is subsequently evaporated. The remaining crystalline product is washed with propanol and dried.

Workup

  1. additionis added to the solution
  2. customis subsequently evaporated
  3. washThe remaining crystalline product is washed with propanol
  4. customdried

Sources & evidence

ORD record
ord-c451687bab2a46079dfc833dbed04ae3
Source dataset
uspto-grants-2014_11
Patent number
US08877799B2

Linked notes

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