HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | diethyl 1H-pyrazole-3,5-dicarboxylate | HCID 142184 | — |
| Reactant | 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole | HCID 11150146 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester | HCID 60207951 | — |
Reaction Steps
To a solution of 1 g 1H-Pyrazole-3,5-dicarboxylic acid diethyl ester in 20 ml of DMF and 188 mg of sodium hydride (60% in mineral oil) were added at RT. After stirring for 20 min at room temperature 1.32 g of 3-bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole were added. The reaction was stirred at room temperature for 3 h. Then 100 ml water were added and the precipitating product was collected by filtration. Yield: 1.7 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429581B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-ac6f8b5ce4bf4aab908a7d48d79f7d5c |
| Source note | uspto-grants-2008_09 |