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HRID33242

反应详情

EQUATION

反应方程式

HRID 33242 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CCOC(=O)c1cc(C(=O)OCC)[nH]n1
HCID142184

3,5-Diethoxycarbonylpyrazole

C9H12N2O4

结构：Clc1ccc(-c2cc(CBr)no2)s1
HCID11150146

3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole

C8H5BrClNOS

PRODUCTS

生成物

1
结构：COC(=O)c1cc(C(=O)OC)n(Cc2cc(-c3ccc(Cl)s3)on2)n1
HCID60207951

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a solution of 1 g 1H-Pyrazole-3,5-dicarboxylic acid diethyl ester in 20 ml of DMF and 188 mg of sodium hydride (60% in mineral oil) were added at RT. After stirring for 20 min at room temperature 1.32 g of 3-bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole were added. The reaction was stirred at room temperature for 3 h. Then 100 ml water were added and the precipitating product was collected by filtration. Yield: 1.7 g.

WORKUP

后处理

  1. additionwere added
  2. filtrationthe precipitating product was collected by filtration