Hydrazinium chloride → HCID 178469379, compound

HRID 33269

Reaction equation

HRID 33269 reaction equation
[Na].[C:2]([O:12][CH2:13][CH3:14])(=[O:11])[CH2:3][C:4]([C:6](OCC)=[O:7])=O.Cl.[NH2:16][NH2:17]>C(O)C.O.Cl>[CH2:13]([O:12][C:2]([C:3]1[NH:16][N:17]=[C:6]([OH:7])[CH:4]=1)=[O:11])[CH3:14]

Participants

6

Reactant 2

HCID 115031Hydrazinium chlorideHCID 57351814Diethyl 2-oxosuccinate,sodium salt

Product 1

HCID 178469379HCID 178469379, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 5 g Diethyl Oxalacetate sodium salt in 100 ml ethanol, 1.5 g hydrazine monohydrochloride were added and the reaction mixture was heated to 80° C. for 3 h. Then the solution was diluted with 100 ml of water containing 3 ml of halfconcentrated HCl and extracted with DCM (3×100 ml). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was subjected to the next reaction step without further purification; Yield: 3.4 g

Workup

  1. extractionextracted with DCM (3×100 ml)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude product was subjected to the next reaction step without further purification

Sources & evidence

ORD record
ord-1eaec0aabaf74bf68499db6ce002e679
Source dataset
uspto-grants-2008_09
Patent number
US07429581B2

Linked notes

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