Isopropylamine → 3-Chloro-N-(propan-2-yl)pyrazin-2-amine
Reaction equation
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:9][CH:10]([NH2:12])[CH3:11]>C1COCC1>[Cl:8][C:7]1[C:2]([NH:12][CH:10]([CH3:11])[CH3:9])=[N:3][CH:4]=[CH:5][N:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2,3-dichloropyrazine (10 g, 67.1 mmol), propan-2-amine (11.90 g, 201 mmol), and 50 mL of THF were mixed in a three-neck flask and stirred at room temperature overnight. The reaction was brought to reflux overnight. The reaction was cooled and the solvent was evaporated. The residue was dissolved in dichloromethane and the salt was filtered. The solvent was then evaporated and the residue was purified by column using dichloromethane as solvent to give 3-chloro-N-isopropylpyrazin-2-amine (6.2 g, 53.8%).
Workup
- temperatureto reflux overnight
- temperatureThe reaction was cooled
- customthe solvent was evaporated
- dissolutionThe residue was dissolved in dichloromethane
- filtrationthe salt was filtered
- customThe solvent was then evaporated
- customthe residue was purified by column
Sources & evidence
- ORD record
- ord-2f52f21493e84c5caa5d10d5da1134e0
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08883322B2
Reaction notes
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