tert-Butyl (3S)-3-(4-quinolylamino)pyrrolidine-1-carboxylate → N-[(3S)-Pyrrolidin-3-yl]quinolin-4-amine
Reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([NH:11][C@H:12]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]2)=[CH:3][CH:2]=1>ClCCl.FC(F)(F)C(O)=O>[NH:14]1[CH2:15][CH2:16][C@H:12]([NH:11][C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[CH:2][CH:3]=2)[CH2:13]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
tert-Butyl (3S)-3-(4-quinolylamino)pyrrolidine-1-carboxylate (231 mg, 0.68 mmol) was dissolved in a 1:1 mixture of dichloromethane and trifluoroacetic acid (2 ml) and stirred at room temperature for 15 minutes. The mixture was evaporated to dryness under reduced pressure and the residue obtained was used directly in the next step.